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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
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1980 1
1981 1
1982 3
1983 4
1984 7
1985 7
1986 12
1987 6
1988 21
1989 24
1990 22
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1993 38
1994 39
1995 44
1996 50
1997 33
1998 33
1999 24
2000 30
2001 20
2002 19
2003 23
2004 23
2005 26
2006 25
2007 28
2008 24
2009 22
2010 24
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2012 25
2013 11
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997 results

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Page 1
An Introduction to Epitope Mapping.
Nilvebrant J, Rockberg J. Nilvebrant J, et al. Methods Mol Biol. 2018;1785:1-10. doi: 10.1007/978-1-4939-7841-0_1. Methods Mol Biol. 2018. PMID: 29714008
The particular area of the antigen recognized by the antibody is called the epitope, and for proteinaceous antigens the epitope can be of complex nature. ...Although the real picture is even more complex, epitopes in protein antigens are broadly grouped into …
The particular area of the antigen recognized by the antibody is called the epitope, and for proteinaceous antigens the epitope …
Mass spectrometric epitope mapping.
Opuni KFM, Al-Majdoub M, Yefremova Y, El-Kased RF, Koy C, Glocker MO. Opuni KFM, et al. Mass Spectrom Rev. 2018 Mar;37(2):229-241. doi: 10.1002/mas.21516. Epub 2016 Jul 12. Mass Spectrom Rev. 2018. PMID: 27403762 Review.
The antibody's resistance towards enzymatic proteolysis has been of key importance for the two mostly applied methods: epitope excision and epitope extraction. Sample consumption has dropped to low pmol amounts on both, the antigen and the antibody. ...The rapidity …
The antibody's resistance towards enzymatic proteolysis has been of key importance for the two mostly applied methods: epitope excisi …
B-Cell Epitope Predictions Using Computational Methods.
Zheng D, Liang S, Zhang C. Zheng D, et al. Methods Mol Biol. 2023;2552:239-254. doi: 10.1007/978-1-0716-2609-2_12. Methods Mol Biol. 2023. PMID: 36346595
To facilitate this process and improve its efficiency, computational methods were developed to predict both linear epitopes and discontinuous antigenic epitopes. For linear B-cell epitope prediction, many methods were developed, including PREDITOP, PEO …
To facilitate this process and improve its efficiency, computational methods were developed to predict both linear epitopes and di …
Discontinuous Epitope Mapping of Antibodies Using Bacterial Cell Surface Display of Folded Domains.
Volk AL, Rockberg J. Volk AL, et al. Methods Mol Biol. 2018;1785:159-183. doi: 10.1007/978-1-4939-7841-0_11. Methods Mol Biol. 2018. PMID: 29714018
Knowledge of the exquisite-binding surface of an antibody on its target protein is of great value, in particular for therapeutic antibodies for understanding method of action and for stratification of patients carrying the necessary epitope for desired drug efficacy, but a …
Knowledge of the exquisite-binding surface of an antibody on its target protein is of great value, in particular for therapeutic antibodies …
PhIP-Seq characterization of serum antibodies using oligonucleotide-encoded peptidomes.
Mohan D, Wansley DL, Sie BM, Noon MS, Baer AN, Laserson U, Larman HB. Mohan D, et al. Nat Protoc. 2018 Sep;13(9):1958-1978. doi: 10.1038/s41596-018-0025-6. Nat Protoc. 2018. PMID: 30190553 Free PMC article.
Compared with protein microarrays, however, PhIP-Seq libraries lack discontinuous epitopes and post-translational modifications. To increase the accessibility of PhIP-Seq, we provide detailed instructions for the design of phage-displayed peptidome libraries, their …
Compared with protein microarrays, however, PhIP-Seq libraries lack discontinuous epitopes and post-translational modification …
Discontinuous epitope prediction based on mimotope analysis.
Moreau V, Granier C, Villard S, Laune D, Molina F. Moreau V, et al. Bioinformatics. 2006 May 1;22(9):1088-95. doi: 10.1093/bioinformatics/btl012. Epub 2006 Jan 24. Bioinformatics. 2006. PMID: 16434442
MOTIVATION: Phage display is a widespread technique used to obtain peptide mimotopes selected by binding to a given monoclonal antibody in a similar way as the native epitope. However, the localization of the interaction site mimicked by the mimotopes on the surface of the …
MOTIVATION: Phage display is a widespread technique used to obtain peptide mimotopes selected by binding to a given monoclonal antibody in a …
The identification of discontinuous epitope in the human cystatin C - Monoclonal antibody HCC3 complex.
Rafalik M, Spodzieja M, Kołodziejczyk AS, Rodziewicz-Motowidło S, Szymańska A, Grubb A, Czaplewska P. Rafalik M, et al. J Proteomics. 2019 Jan 16;191:58-67. doi: 10.1016/j.jprot.2018.04.020. Epub 2018 Apr 22. J Proteomics. 2019. PMID: 29684685
Comprehensive analysis of the obtained results allowed us to identify the epitope sequence with the key fragment covering hCC L1 loop and two potential epitopic fragments - alpha-helical part, hCC (17-28) and beta4 strand in C-terminal part of hCC. The presence of t …
Comprehensive analysis of the obtained results allowed us to identify the epitope sequence with the key fragment covering hCC L1 loop …
Characterization of a discontinuous epitope of the human immunodeficiency virus (HIV) core protein p24 by epitope excision and differential chemical modification followed by mass spectrometric peptide mapping analysis.
Hochleitner EO, Borchers C, Parker C, Bienstock RJ, Tomer KB. Hochleitner EO, et al. Protein Sci. 2000 Mar;9(3):487-96. doi: 10.1110/ps.9.3.487. Protein Sci. 2000. PMID: 10752610 Free PMC article.
Moreover, no affinity-bound fragments were observed after an epitope extraction experiment. These data from the epitope excision and extraction experiments suggest that the epitope is discontinuous. ...However, the N-terminal amino group was found to b …
Moreover, no affinity-bound fragments were observed after an epitope extraction experiment. These data from the epitope excisi …
Mapping invisible epitopes by NMR spectroscopy.
Usher ET, Showalter SA. Usher ET, et al. J Biol Chem. 2020 Dec 18;295(51):17411-17412. doi: 10.1074/jbc.H120.016607. J Biol Chem. 2020. PMID: 33453987 Free PMC article.
Defining discontinuous antigenic epitopes remains a substantial challenge, as exemplified by the case of lipid transfer polyproteins, which are common pollen allergens. Hydrogen/deuterium exchange monitored by NMR can be used to map epitopes onto folded prote …
Defining discontinuous antigenic epitopes remains a substantial challenge, as exemplified by the case of lipid transfer polypr …
Epitope Mapping of Antibody-Antigen Interactions with X-Ray Crystallography.
Toride King M, Brooks CL. Toride King M, et al. Methods Mol Biol. 2018;1785:13-27. doi: 10.1007/978-1-4939-7841-0_2. Methods Mol Biol. 2018. PMID: 29714009 Free PMC article.
In many cases the epitope recognized by the antibody is a complex, discontinuous 3D conformational epitope. ...An X-ray structure allows for inspection of specific antibody-antigen interactions, even in the case of complex conformational epitopes. The …
In many cases the epitope recognized by the antibody is a complex, discontinuous 3D conformational epitope. ...An X-ray …
997 results